Kuljeet is a computational biologist and interested in wide spectrum of biological questions. Some of the questions that his group is presently working on are as following:

 

1. What  are  the  evolutionary  constraints  governing  non-random  linear  and  3-dimensional organization of eukaryotic genome?
2. What explains the global disconnect between location and effect of chromatin factors.
3. What  determines  the  epigenetic  accessibility,  or  lack  thereof,  of  mono  and  bi-allelically expressed genes to the activation/repression machinery?
4. What are the major determinants of transcriptional noise in the eukaryotic genome?
5. How do epigenetic errors radiate across different networks in the cell?
6. How do long structurally disordered regions in the proteins recognize DNA elements?
7. Are  the  left-handed  glycyl  residues  evolutionarily  selected  to  surrogate  D-amino  acid conformation in proteins?

 
For more details visit:   Group Page

• Sandhu KS*, Guoliang Li, Huay Mei Poh, Yu Ling Kelly Quek, Yee Yen Sia, Su Qin Peh, Fabianus Hendriyan Mulawadi, Mile Sikic, Francesca Menghi, Anbupalam Thalamuthu, Wing Kin Sung, Xiaoan Ruan, Melissa Jane Fullwood,   Edison Liu,   Peter Csermely, Yijun Ruan^*  . Large scale functional  organization  of  long-range  chromatin  interaction  networks.  Cell  Rep.  2012  Nov 29;2(5):1207-19.
• Sandhu KS*. Did the modulation of expression noise shape the evolution of three dimensional genome organizations? Nucleus 2012; 3:3,1-4.
• Li  G#,  Ruan  X#, Auerbach  R#,  Sandhu  KS#  et  al. Extensive  promoter  centered  chromatin interactions provide a architectural basis for transcription regulation in eukaryotes. Cell. 2012 Jan 20;148(1-2):84-98 (#co-first author)
• Sandhu KS*. Systems properties of proteins encoded by imprintedse genes. Epigenetics 2010 Oct 01,5 (7).
• Sandhu KS, Shi C, Sjolinder M, Zhao Z, Gondor A, Liu L, Tiwari VK, Guibert S, Emilsson L, Imreh MP,  Ohlsson  R*.  Nonallelic  transvection  of  multiple  imprinted  loci  is  organized  by  the  H19 imprinting control region during germline development. Genes Dev. 2009; Nov 15; 23: 2592-2597.
• Sandhu KS*. Intrinsic disorder explains diverse nuclear roles of chromatin remodeling proteins. J Mol Recognit. 2009 Jan-Feb;22(1):1-8.
• Sandhu KS, Dash D*. Dynamic alpha-helices: conformations that do not conform. Proteins. 2007 Jul 1;68(1):109-22
• Sandhu  KS,  Dash  D*.  Conformational  flexibility  may  explain  multiple  cellular  roles  of  PEST motifs. Proteins. 2006 Jun 1;63(4):727-32
• Sandhu   KS,   Acharya   KK*.   ExPrimer:   to   design   primers   from   exon–exon   junctions. Bioinformatics. 2005 May 1;21(9):2091-2.